AUSTRIA


Dr. Roland Foisner
Max F. Perutz Laboratories, Medical University
Dr. Bohr-Gasse 9, Room: 3.113, 1030 Vienna
Phone: +43-1-4277-61680

Web


Facilities

Equipment and facilities of the group and centre: Equipment for basic molecular biology research. Facilities on Campus include mouse facility, mouse phenotyping, mass spectrometry, Next Generation Sequencing, Biooptics (Light Microscopy, FACS), Super-resolution Microscopes (PALM, SIM), Electron Microscopy.


Topics of interest

  • Dynamics and Regulation of Lamins 

  • Lamin-Chromatin Interaction on genome wide level

  • Lamin-Interacting proteome

  • Lamina-associated protein as major regulators of lamin structure and function

  • Role of lamin complexes (particularly nucleoplasmic lamins) in tissue progenitor cells (muscle, adipocytes, epidermal stem cells)

  • Effect of laminopathic mutations on lamin dynamics and function 


Publications

  • Brachner A, Foisner R. 2014. Lamina-Associated Polypeptide (LAP)2α and Other LEM Proteins in Cancer Biology. Adv Exp Med Biol. 773: 143-63.
  • Gesson K, Vidak S, Foisner R. 2013. Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease.  Semin Cell Dev Biol. pii: S1084-9521(13)00138-9. 
  • Zhang S, Schones DE, Malicet C, Rochman M, Zhou M, Foisner R, Bustin M. 2013. High mobility group protein N5 (HMGN5) and lamina-associated polypeptide 2α (LAP2α) interact and reciprocally affect their genome-wide chromatin organization.  J Biol Chem. 288(25): 18104-9.
  • Cohen TV, Gnocchi VF, Cohen JE, Phadke A, Liu H, Ellis JA, Foisner R, Stewart CL, Zammit PS, Partridge TA. 2013. Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α. Hum Mol Genet. 22(14): 2852-69
  • Pilat U, Dechat T, Bertrand AT, Woisetschläger N, Gotic I, Spilka R, Biadasiewicz K, Bonne G, Foisner R. 2013. The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice. J Cell Sci. 126(Pt 8): 1753-62.
  • Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL, Leonhardt H, Joffe B. 2013. LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell. 152(3): 584-98.
  • Brachner A, Braun J, Ghodgaonkar M, Castor D, Zlopasa L, Ehrlich V, Jiricny J, Gotzmann J, Knasmüller S, Foisner R. 2012. The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J Cell Sci. 125(Pt 4): 1048-57.
  • A. Brachner, R. Foisner. 2011. Evolvement of LEM proteins as chromatin tethers at the nuclear periphery. Biochem Soc Trans 39, 1735-1741.
  • Dechat T, Gesson K, Foisner R. 2011. Lamina-independent lamins in the nuclear interior serve important functions. Cold Spring Harb Symp Quant Biol. [Epub ahead of print] PMID: 21209392.
  • Brachner A, Foisner R. Cell Cycle. 2011. Lamins reach out to novel functions in DNA damage repair. 10(20): 3426.
  • Gotic I, Foisner R. Nucleus. 2010. Multiple novel functions of lamina associated polypeptide 2α in striated muscle. 1(5): 397-401
  • Roblek M, Schüchner S, Huber V, Ollram K, Vlcek S, Foisner R, Wehnert M, Ogris E. 2010. Monoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482W. PloS ONE, 5(5) e10604. doi:10.1371/journal.pone.0010604.
  • Wilson KL, Foisner R. 2010. Lamin-binding proteins. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a000554
  • Gotic I, Schmidt WM, Biadasiewicz K, Leschnik M, Spilka R, Braun J, Stewart CL, Foisner R. 2010. Loss of LAP2alpha Delays Satellite Cell Differentiation and Affects Postnatal Fiber Type Determination. Stem Cells. 2010, 28: 480-488.
  • Gotic I, Leschnik M, Kolm U, Markovic M, Haubner BJ, Biadasiewicz K, Metzler B, Stewart CL, Foisner R. 2010. Lamina-Associated Polypeptide 2{alpha} Loss Impairs Heart Function and Stress Response in Mice. Circ. Res. 106(2): 346-53.
  • Naetar, N., B. Korbei, S. Kozlov, M.A. Kerenyi, D. Dorner, R. Kral, I. Gotic, P. Fuchs, T.V. Cohen, R. Bittner, C.L. Stewart, and R. Foisner. 2008. Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation. Nat Cell Biol. 10: 1341-1348.
  • Capanni, C., R. Del Coco, S. Squarzoni, M. Columbaro, E. Mattioli, D. Camozzi, A. Rocchi, K. Scotlandi, N. Maraldi, R. Foisner, and G. Lattanzi. 2008. Prelamin A is involved in early steps of muscle differentiation. Exp Cell Res. 314: 3628-3637.
  • D. Dorner, S. Vlcek, Nicole Foeger, Andreas Gajewski, C. Makolm, J. Gotzmann, C.J. Hutchison, and R. Foisner. 2006. Lamina-associated polypeptide 2α regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J. Cell Biol. 173: 83-93.
  • Gotzmann, J., and R. Foisner. 2006. A-type lamin complexes and regenerative potential: a step towards understanding laminopathic diseases? Histochem. Cell Biol. 125: 33-41.


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