Prof C. J. Hutchison

Durham University Biosciences
South Road, Durham DH1 3LE
Phone: 0191 334 1270


Hutchison group
Hutchison is Professor of Cell Biology in the School of Biological and Biomedical Sciences. He has 34 years research experience in cell culture and cell biology with a focus on the role of nuclear envelope proteins in human health and disease. He completed his PhD studies at the Institute of Neurology, University College London and was a research fellow for six years at the University of Sussex before being appointed as lecturer in the School of Life Sciences, University of Dundee. He was appointmented as Chair of Cell Biology at the University of Durham in 2000. His lab focuses on the role of nuclear lamins and lamina associated proteins in cell signalling and development, including their roles in Rb signalling, β-catenin signalling, ROS signalling, DNA damage response and adipogenesis. Recently, Hutchison was awarded a £2.2M award by BBSRC, in collaboration with Procter & Gamble and LifeTechnologies corp, to develop full thickness organotypic models of skin and ageing, to replace the use of animals in skin health product development.

Jahoda Group
Jahoda is Professor in the School of Biological and Biomedical Sciences at Durham University. He obtained his PhD from the University of Dundee, and worked as a postdoc and then assistant lecturer at the University of Grenoble, France between 1982 and 1984. He returned to Dundee University as a postdoc, where he subsequently started his own laboratory, first as a Royal Society University Research Fellow and then as a lecturer. Since 1991 he has been at Durham, and is currently co director of NESCI, North East England Stem Cell Institute. His main research topics are epithelial-mesenchymal interactions and the control of skin appendage development; human hair follicle induction; transdifferentiation and reprogramming of epithelial cells, hair follicle-derived mesenchymal stem cells; and the development of in vitro skin models.  Of his main areas of current interest is development of a separate adipose depot in skin, and the implications of this for adipose stem cells and aspects of disease.


Karakesisoglou Group
Karakesisoglou is a senior lecturer at the School of Biological and Biomedical Sciences. He has 15 years of research experience in epithelial cell biology and ageing, and has published over 27 research articles. He completed his post-doctoral training at the world-renowned skin laboratory of Professor Elaine Fuchs at the University of Chicago. There, he pioneered a novel field in cell biology of how cytoskeletal linker proteins (spectraplakins) determine skin tissue architecture and homeostasis (Karakesisoglou et al., 2000; Kodama et al., 2003). His research in Durham aims to characterize the molecular links (i.e. Linker of the Nucleoskeleton and Cytoskeleton, termed LINC complex), governing the integration of the nuclear and cytoplasmic compartments in skin cells and to elucidate their role in tissue morphogenesis and degeneration using 3D in vitro cell models and mouse genetics. Work in his laboratory established novel roles for LINC proteins in skin wound healing (Rashmi et al. Nucleus, 2012), skin thickness regulation (Luke et al. J. Cell Sci, 2008), cyto-architecture (Schneider et al. Cell. Mol. Life Sci. 2011; Lu et al. Cell. Mol. Life Sci. 2012) and key ageing signalling pathways (i.e. NF-kB, TGF-beta and Wnt; Neumann et al. J. Biol. Chem. 2010; Rashmi et al. 2012).


Equipment and facilities of the group and centre

Animal House Facilities, electron microscopy facilities, live cell imaging facilities and 3D live imaging (spinning disc), confocal,TIRF, FLIM, FCCS, 3 dimensional cell culture, proteomics service, DNA sequencing service including exome sequencing.


Publications from the Hutchison group

  • Hutchison C J and Worman, H J (2004) Lamin A: A Guardian of the Soma? Nature Cell Biology. 6 (11) 1062 - 1067
  • Van Berlo JH, Voncken JW, Kubben N, Broers JL, Duisters R, van Leeuwen RE, Crijns HJ, Ramaekers FC, Hutchison CJ, Pinto YM. (2005) A-type lamins are essential for TGF-beta1 induced PP2A to dephosphorylate transcription factors. Hum Mol Genet: 14: 2839 – 2849
  • Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. (2005) Genomic instability in laminopathy-based premature aging. Nat Med. 11(7):780-5.
  • Van Engelen, B., Muchir A., Hutchison C J., van der Kooi A J., Bonne, G and Lammens M., (2005) The lethal phenotype of a homozygous nonsense mutation in the lamin A/C gene Neurology 64: 374 - 376.
  • Markiewicz, E.M., Ledren M and Hutchison C J (2005) Remodelling of the nucleoskeleton is required for skeletal muscle differentiation in vitro. J. Cell Sci. 118:409 – 420
  • Markiewicz E, Tilgner K, Barker N, van de Wetering M, Clevers H, Dorobek M, Hausmanowa-Petrusewicz I, Ramaekers FC, Broers JL, Blankesteijn WM, Salpingidou G, Wilson RG, Ellis JA, Hutchison CJ. (2006) The inner nuclear membrane protein Emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J 25:3275-85
  • Broers JL, Ramaekers FC, Bonne G, Yaou RB, Hutchison CJ. (2006) Nuclear lamins: laminopathies and their role in premature ageing. Physiol Rev. 86(3): 967-1008
  • Pekovic, V, Harborth, J, Broers, JLV, Ramaekers, FCS, van Engelen, B, Lammens, M, von Zglinicki, T, Foisner, R, Hutchison, C & Markiewicz, E (2007). Nucleoplasmic LAP2 alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. Journal of Cell Biology 176(2): 163-172
  • Dorner D, Vlcek S, Foeger N, Gajewski A, Makolm C, Gotzmann J, Hutchison CJ, Foisner R. (2006) Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J Cell Biol. 173(1): 83-93
  • Salpingidou, G, Smertenko, A, Hausmanowa-Petrucewicz, I, Hussey, PJ & Hutchison, CJ (2007). A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane. Journal of Cell Biology 178(6): 897-904.
  • Goldberg MW, Huttenlatch, I, Hutchison CJ and Stick R (2008). Filament made from A-type and B-type lamins differ in structure and organization. J Cell Sci 121: 215-225
  • Pekovic V, Hutchison CJ (2008) Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. J Anat. 213(1):5-25
  • Willis ND, Przyborski SA, Hutchison CJ, Wilson RG (2008).Colonic and colorectal cancer stem cells: progress in the search for putative biomarkers.J Anat. 2008 Jul;213(1):59-65.
  • Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A, Hutchison CJ. (2008) Lamin A/C is a risk biomarker in colorectal cancer. PLoS ONE.;3(8):e2988
  • Willis ND, Wilson RG, Hutchison CJ (2009) Lamin A: a putative colonic epithelial stem cell biomarker which identifies colorectal tumours with a more aggressive phenotype.Biochem Soc Trans. 36(Pt 6):1350-3 
  • Tilgner K, Wojciechowicz K, Jahoda C, Hutchison C, Markiewicz E. (2009) Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of {beta}-catenin. J Cell Sci. 122(Pt 3):401-13
  • Columbaro M, Mattioli E, Schena E, Capanni C, Cenni V, Levy N, Navarro CL, Del Coco R, Squarzoni S, Camozzi D, Hutchison CJ, Wehnert M, Lattanzi G.(2010) Prelamin A processing and functional effects in Restrictive Dermopathy Cell Cycle 9: 47 – 56
  • Foster CR, Przyborski SA, Wilson RG, Hutchison CJ. (2010) Lamins as cancer biomarkers. Biochem Soc Trans. 2010 Feb;38(Pt 1):297-300
  • Richards SA, Muter J, Ritchie P, Lattanzi G, Hutchison CJ (2011) The accumulation of unrepairable DNA damage in laminopathy progeroid syndromes is caused by ROS generation and is prevented by treatment with N-acetyl cysteine. Hum. Mol. Genet. 20: epub ahead of print.
  • Vanja Pekovic, Ian Gibbs-Seymour, Ewa Markiewicz, Fahad Alzoghaibi, Adam M. Benham, Robert Edwards, Manfred Wenhert, Thomas von Zglinicki and Christopher J. Hutchison (2011) Conserved cysteine residues in the lamin A tail are essential for cellular responses to ROS generation. Ageing Cell epub ahead of print.
  • Clare R Foster, Joanne L Robson, William Simon, Jeremy Twigg, Derek Cruikshank, Robert Wilson & Christopher J Hutchison (2011) The role of lamin A in cytoskeleton organisation: A proteomic approach. Nucleus 2(5) 1 – 10
  • Nadia Korfali., Vlastimil Srsen., Martin Waterfall, Dzmitry G. Batrakou, Vanja Pekovic, Christopher J. Hutchison, Eric C. Schirmer (2011) A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal Plos One 6(4) e18762
  • Hutchison CJ (2011) The role of DNA damage in laminopathy progeroid syndromes, Biochem Soc Trans. 39: 1715 0 1718
  • Chmielewska M, Dubińska-Magiera M, Sopel M, Rzepecka D, Hutchison CJ, Goldberg MW, Rzepecki R (2011) Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope Cell Tiss Research 344: 97 – 110
  • Hill RP, Gledhill K, Gardner A, Higgins CA, Crawford H, Lawrence C, Hutchison CJ, Owens WA, Kara B, James SE, Jahoda CA.(2012) Generation and characterization of multipotent stem cells from established dermal cultures. PLoS One. 2012;7(11):e50742
  • Hutchison CJ (2012) B-type lamins and their elusive roles in cell proliferation and senescence. EMBO J 31: 1058  - 1059.
  • Hutchison CJ (2013) B-type lamins in health and disease. Sem. Cell and Dev. Biol. S1084-9521(13) 0014-9.


Publications from the Jahoda Group

  • Tilgner K, Wojciechowicz K, Jahoda C, Hutchison C, Markiewicz E. (2009) Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of {beta}-catenin. J Cell Sci.122:401-13. 
  • Higgins CA, Westgate GE, Jahoda CA. (2009) From telogen to exogen: mechanisms underlying formation and subsequent loss of the hair club fiber. J Invest Dermatol.129(9):2100-8. 
  • Waters JM, Richardson GD, Jahoda CA. (2009) Keratin 10 (K10) is expressed suprabasally throughout the limbus of embryonic and neonatal rat corneas, with interrupted expression in the adult limbus. Exp Eye Res. 89(3):435-8. 
  • Richardson GD, Fantauzzo KA, Bazzi H, Määttä A, Jahoda CA. (2009) Dynamic expression of Syndecan-1 during hair follicle morphogenesis.
  • Gene Expr Patterns. 9(6):454-60. 
  • Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA. (2009) KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development. 136(13):2153-64. 
  • Guo A, Jahoda CA.(2009) An improved method of human keratinocyte culture from skin explants: cell expansion is linked to markers of activated progenitor cells. Exp Dermatol. 18(8):720-6.
  • Higgins CA, Richardson GD, Westgate GE, Jahoda CA.(2009) Exogen involves gradual release of the hair club fibre in the vibrissa follicle model. Exp Dermatol. 18(9):793-5.
  • Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM.(2010) Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. 466:113-7.
  • Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CA.(2010) Modelling the hair follicle dermal papilla using spheroid cell cultures. Exp Dermatol.19(6):546-8. 
  • Guo A, Song B, Reid B, Gu Y, Forrester JV, Jahoda CA, Zhao M. (2010) Effects of physiological electric fields on migration of human dermal fibroblasts. J Invest Dermatol. 130(9):2320-7.
  • Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CA.(2010) Modelling the hair follicle dermal papilla using spheroid cell cultures. Exp Dermatol. 19(6):546-8. 
  • Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Sing P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM.(2010) Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. 2010 Jul 1;466(7302):113-7.
  • Higgins CA, Westgate GE, Jahoda CA.(2011) Modulation in proteolytic activity is identified as a hallmark of exogen by transcriptional profiling of hair follicles. J Invest Dermatol.131(12):2349-57. 
  • Jahoda CA, Christiano AM.(2011) Niche crosstalk: intercellular signals at the hair follicle. Cell.;146(5):678-81.
  • Hill RP, Haycock JW, Jahoda CA. (2012) Human hair follicle dermal cells and skin fibroblasts show differential activation of NF-κB in response to pro-inflammatory challenge. Exp Dermatol, 21(2):158-60. 
  • Guo A, Owens WA, Coady M, Liu D, Jahoda CA.(2012) An in vivo mouse model of human skin replacement for wound healing and cell therapy studies. J Plast Reconstr Aesthet Surg. 65(8):1129-31. 
  • Higgins CA, Itoh M, Inoue K, Richardson GD, Jahoda CA, Christiano AM.(2012) Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells. J Invest Dermatol. 132(6):1725-7.
  • Bell E, Richardson GD, Jahoda CA, Gledhill K, Phillips HM, Henderson D, Owens WA, Hole N.(2012) Dermal stem cells can differentiate down an endothelial lineage. Stem Cells Dev. 2012 Nov 1;21(16):3019-30.
  • Hill RP, Gledhill K, Gardner A, Higgins CA, Crawford H, Lawrence C, Hutchison CJ, Owens WA, Kara B, James SE, Jahoda CA.(2012) Generation and characterization of multipotent stem cells from established dermal cultures. PLoS One. 2012;7(11):e50742
  • Gledhill K, Gardner A, Jahoda CA.(2013) Isolation and establishment of hair follicle dermal papilla cell cultures. Methods Mol Biol. 989:285-92. 
  • Hill RP, Gardner A, Crawford HC, Richer R, Dodds A, Owens WA, Lawrence C, Rao S, Kara B, James SE, Jahoda CA.(2013) Human hair follicle dermal sheath and papilla cells support keratinocyte growth in monolayer coculture. Exp Dermatol. 22(3):236-8. 
  • Wojciechowicz K, Gledhill K, Ambler CA, Manning CB, Jahoda CA.(2013) Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4. PLoS One.8(3):e59811
  • Higgins CA, Chen JC, Cerise JE, Jahoda CA, Christiano AM.(2013) Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. Proc Natl Acad Sci U S A.110(49):19679-88.
  • Dayal JH, Cole CL, Pourreyron C, Watt SA, Lim YZ, Salas-Alanis JC, Murrell DF, McGrath JA, Stieger B, Jahoda C, Leigh IM, South AP.(2013) Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes. J Cell Sci. 2013.


Publications from the Karakesisoglou Group

  • Lu W., Schneider M., Neumann S., Jaeger V.M., Taranum S., Munck, M., Cartwright, S., Richardson C., Carthew, J., Noh, W., Goldberg M., Noegel A., and Karakesisoglou I. Nesprin interchain associations control nuclear size. Cell. Mol. Life Sci. 69, 3493-3509. (2012) Citations: 5
  • Rashmi R.N., Eckes B., Glöckner G., Groth M., Muller R., Munck M., Neumann S., Gloy J., Sellin L., Walz G., Schneider M., Karakesisoglou I., Eichinger L., and Noegel A.A. Roles for nuclear envelope associated Nesprin-2 Giant in cell differentiation, proliferation and chromatin association in a mouse model. Nucleus 3, 1-15. (2012) Citations: 4 
  • Schneider M., Lu W., Neumann S., Brachner A., Gotzmann J., Noegel A.A., and Karakesisoglou I. Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. Cell. Mol. Life Sci. 68, 1593-1610. (2011) Citations: 20
  • Neumann S., Schneider M., Lu W., Eming S., Beijer A., Daugherty R.L., Noegel A.A., and Karakesisoglou I. Nesprin-2 interacts with -Catenin and regulates Wnt-signalling at the nuclear envelope. J. Biol. Chem. 285, 34932-34938. (2010) Citations: 12
  • Lüke Y., Zaim H., Karakesisoglou I., Jaeger V.M., Sellin L., Lu W., Schneider M., Neumann S., Beijer A., Munck M., Padmakumar V.C., Gloy J., Walz G., and Noegel A.A. Nesprin-2 Giant/NUANCE maintains nuclear envelope architecture and composition in skin. J. Cell Sci. 121, 1887-1898. (2008) Citations: 51, Shared first co-authorship 
  • Kodama A., Karakesisoglou I., Wong E., Vaezi A., and Fuchs E. ACF7: a novel integrator of microtubule dynamics. Cell 115, 343-354. (2003) Citations: 145, Shared first co-authorship
  • Karakesisoglou I., Yang Y., and Fuchs E. An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J. Cell Biol. 149, 195-208. (2000) Citations: 96


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